Computational fluid dynamics simulations of mitral paravalvular leaks in the human heart

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main source(s): Warsaw University Technology - BIOTECHMED-3 project under the program Excellence Initiative: Research University. Background Presence paravalvular leaks (PVL) can lead to hemolysis and high shear stress that affects erythrocytes passing through PVL channels may be main reason behind this pathology. In vitro, forces above 300 Pa cause erythrocyte destruction. Distribution currently precisely determined with computational fluid dynamics (CFD). CFD is a numerical modelling method based on solving equations differential balance mass, momentum energy for small section known as cell. Purpose To investigate magnitude affect in define properties increase likelihood hemolysis. Methods Models left-sided heart chambers artificial mitral valves PVLs were created cardiac computed tomography data from subjects PVLs. Computational principles applied create patterns blood flow channels. 4 cross-sectional areas (CSA) 26.2 mm2 (model I), 15.7 2), 20.4 3) 32 4) examined. Length was 6.5, 9.5, 7.3 3.25 mm respectively. models I,III IV channel located anteriorly around annulus, whereas model II posterior location described. Blood simulated using commercial software (ANSYS Fluent 2020R1). Simulations performed rate 60 beats per minute. The following variables examined regarding channels: wall stress, fluid, volume which exceeded duration exposure red cells Pa. Obtained values compared lactate dehydrogenase (LDH) activities whose CTs used models. One left ventricle presented picture 1. Studied are 2. Results all value exceeded. Maximal maximal not related CSA channel. Lowest obtained 2, had longest location. lowest LDH activity noted 2) highest both exceeding III). Conclusions always accompanied by some degree Shear these Volume exceeds influence severity